Avaliação psicossocial e disfunção temporomandibular em graduandos em Odontologia / Evaluación psicosocial y disfunción temporomandibular en estudiantes de pregrado en Odontología / Psychosocial evaluation and temporomandibular dysfunction in undergraduate Dentistry students

O presente estudo objetivou analisar a ocorrência de fatores psicossociais e disfunção temporomandibular (DTM) em graduandos em Odontologia. Realizou-se um estudo transversal, quantitativo, descritivo e analítico. Para a coleta de dados foram utilizados 3 questionários validados, a fim de avaliar o senso de coerência (SOC), ansiedade, depressão e DTM dos discentes, além de perguntas relacionadas ao desenvolvimento acadêmico. Houve adesão de 108 estudantes, 75% do sexo feminino e 49,1% se autoavaliaram com sintomas de DTM. Aproximadamente 36% obtiveram níveis baixos de ansiedade, sendo maior nas mulheres. A maioria encontra-se satisfeito com o desempenho acadêmico, apesar da dificuldade de aprendizado, insatisfação com a rotina e medo de falar em público. A glossofobia foi estatisticamente mais frequente entre as mulheres. Ainda, nos períodos intermediários identificou-se maior insatisfação com a rotina. O SOC médio dos participantes foi de 56,67±8,27 e mostrou-se mais baixo naqueles com elevados níveisde depressão. A ansiedade em níveis altos foi associada com os sintomas de DTM. Portanto, conclui-se que cerca de metade dos discentes de Odontologia apresenta algum sinal de DTM, ansiedade e depressão em níveis baixos, SOC mediano e satisfação com o desempenho acadêmico, apesar das adversidades curriculares (AU).

El presente estudio tuvo como objetivo analizar la aparición de factores psicosociales y Disfunción de Articulación Temporomandibular (DTM) en estudiantes de Odontología. Se realizó un estudio transversal, cuantitativo, descriptivo y analítico. Para la recolección de datos se utilizaron 3 cuestionarios validados, con el fin de evaluar el sentido de coherencia (SC), ansiedad, depresión y DTM de los estudiantes, además de preguntas relacionadas con el desarrollo académico. Participaron 108 estudiantes, 75% mujeres y 49,1% autoevaluados con síntomas de DTM. Aproximadamente el 36% tenía niveles bajos de ansiedad, siendo mayores en las mujeres. La mayoría está satisfecha con su rendimiento académico, a pesar de las dificultades de aprendizaje, la insatisfacción con su rutina y el miedo a hablar en público. La glosofobia fue estadísticamente más común entre las mujeres. Además, en los periodos intermedios se identificó mayor insatisfacción con la rutina. El SC promedio de los participantes fue 56,67 ± 8,27 y fue menor en aquellos con altos niveles de depresión. Un alto nivel de ansiedad se asoció con síntomas de DTM. Por lo tanto, se concluye que aproximadamente la mitad de los estudiantes de Odontología presentan algún signo de DTM, ansiedad y depresión en niveles bajos, SC promedio y satisfacción con el rendimiento académico, a pesar de las adversidades curriculares (AU).

The present study aimed to analyze the occurrence of psychosocial factors and temporomandibular dysfunction (TMD) in undergraduate Dentistry students. A cross-sectional, quantitative, descriptive and analytical study was accomplished. For data collection, 3 validated questionnaires were used, in order to evaluate the students' sense of coherence (SOC), anxiety, depression and TMD, in addition to questions Avaliação psicossocial e disfunção temporomandibular em graduandos em Odontologia related to academic development. 108 students participated, 75% female and 49.1% self-assessed as having TMD symptoms. Approximately 36% had low levels of anxiety, being higher in women. The majority are satisfied with their academic performance, despite learning difficulties, dissatisfaction with their routine and fear to speak in public. The glossophobia was statistically more frequent in women. Also, in intermediate periods it was identified a higher level of dissatisfaction with routine. The sense of coherence was 56,67± 8,27 and it demonstrated lower in those with high levels of depression. The anxiety in high levels was associated with DTM symptoms. Therefore, it is concluded that nearly half of Dentistry students present any of DTM symptoms, anxiety and depression in lower levels, median SOC and satisfaction with academic performance, despite curricular adversities (AU).

Wnt signalling in oral and maxillofacial diseases.

Wnts include more than 19 types of secreted glycoproteins that are involved in a wide range of pathological processes in oral and maxillofacial diseases. The transmission of Wnt signalling from the extracellular matrix into the nucleus includes canonical pathways and noncanonical pathways, which play an important role in tooth development, alveolar bone regeneration, and related diseases. In recent years, with the in-depth study of Wnt signalling in oral and maxillofacial-related diseases, many new conclusions and perspectives have been reached, and there are also some controversies. This article aims to summarise the roles of Wnt signalling in various oral diseases, including periodontitis, dental pulp disease, jaw disease, cleft palate, and abnormal tooth development, to provide researchers with a better and more comprehensive understanding of Wnts in oral and maxillofacial diseases.

The influence of cervical spine rehabilitation on bioelectrical activity (sEMG) of cervical and masticatory system muscles.

BACKGROUND: Coexistence of temporomandibular joint discomfort along with cervical spine disorders is quite common, and is associated with many limitations and adverse symptoms for the patient. Both diagnostics and treatment of these ailments are difficult, and in many cases, the effects of therapy are not satisfactory. This study assessed the impact of a 3-week neck-only rehabilitation programme without direct intervention in the craniofacial area on the bioelectric activity of both the cervical spine and muscles in the craniofacial area among patients with idiopathic neck pain who do not report TMJ pain. DESIGN: A parallel group trial with follow-up; Setting: Rehabilitation Clinic. METHODS: Twenty five patients experiencing idiopathic neck pain underwent the 3-week rehabilitation programme. Thirty five age-matched subjects with no cervical spine and temporomandibular joint (TMJ) dysfunctions were control group. At baseline and after 3 weeks the cervical and craniofacial area muscles' bioelectrical activity (sEMG) was evaluated. RESULTS: In the experimental group during cervical flexion, a significant decrease of sEMG amplitude was noted in the right (mean 25.1 µV; 95% CI: 21.5-28.6 vs mean 16.8 µV; 95% CI: 13.8-19.7) and left (mean 25.9 µV; 95% CI: 21.7-30.0 vs mean 17.2 µV; 95% CI: 13.6-20.7) Sternocleidomastoid as well as a significant increase in sEMG amplitude of the right (mean 11.1 µV; 95% CI: 7.9-14.2 vs mean 15.7 µV; 95% CI: 12.1-19.2) and left (mean 15.3 µV; 95% CI: 11.9-18.6 vs mean 20.2 µV; 95% CI: 15.7-24.2) Upper Trapezius muscles. In the experimental group, after therapy right and left Sternocleidomastoid, Temporalis Anterior and Masseter muscles presented lower fatigue levels. CONCLUSIONS: Three weeks of rehabilitation without any therapeutic intervention in temporomandibular joint significantly decreased the bioelectrical activity of the neck and craniofacial muscles while improving the muscle pattern of coactivation in participants with idiopathic neck pain who do not report temporomandibular joint pain. These observations could be helpful in the physiotherapeutic treatment of neck and craniofacial area dysfunctions. TRIAL REGISTRATION: ID ISRCTN14511735-retrospectively registered.

Avaliação da amplitude de abertura bucal em pacientes com disfunção temporomandibular após tratamento com terapia manual / Evaluation of mouthopening amplitude in patients with temporomandibular disorder after treatment with manual therapy / Evaluación de la amplitud de aperturade la bocaen pacientes con transtorno temporomandibulardespués del tratamiento con terapia manual

Introdução:A disfunção temporomandibular,distúrbio que acomete as estruturas ósseas, musculares e articulares da região orofacial tem sido cada vez mais recorrente. Esse distúrbio causa dores, limitação de movimento e alteração na qualidade de vida dos pacientes acometidos com a doença. Se fazemnecessáriasmedidas de controle e tratamento dessadoença de prevalência crescente. Objetivo:Avaliar a amplitude de abertura bucal em pacientes portadores de disfunção temporomandibular, submetidos ao tratamento com fisioterapia após 1 e 3 meses de tratamento.Metodologia:Avaliou-se a amplitude de abertura bucal de 25 pacientes submetidos ao tratamento com fisioterapia. Todos os pacientes foram diagnosticados com disfunçãode acordo com o eixo 1 do "Research Diagnostic Criteria for Temporomandibular Disorders". Os dados colhidos foram avaliados através do programa SPSS e foi realizado o teste Wilcoxon, com nível de confiança de 95%. Resultados:Para pacientes que apresentavam comprometimento da amplitude de abertura máxima sem auxílio, a fisioterapia possibilitou melhora significativa do ganho de amplitude no tempo inicial e após um mês de terapia (p= 0,002), mantendo a amplitude até o terceiro mês, sem apresentar ganho significativo. Conclusões:Para a variável amplitude de abertura bucal, a fisioterapia se mostra como uma boa alternativa de tratamento, alcançando resultados satisfatórios para o ganho de amplitude e melhoria do quadro sintomático do paciente (AU).

Introduction:Temporomandibulardisorder, a disorder that affects bone, muscle and joint structures in the orofacial region has been increasingly recurrent. This disorder causes pain, movement limitation and changes in the quality of life of patients affected by the disease. Control measures and treatment of the disease of increasing prevalence are necessary. Objective:To evaluate the range of mouth opening in patients undergoing treatment with physiotherapy after 1 and 3 months of treatment. Methodology:It was the amplitude of mouth opening in 25 patients submitted to treatment with physiotherapy. All patients were diagnosed with disorder according to axis 1 of the Research Diagnostic Criteria for Temporomandibular Disorders. The collected data were evaluatedusing the SPSS program and the Wilcoxon test was performed, with a 95% confidence level. Results:For patients who presented impairment of the maximum opening amplitude without assistance, physiotherapy enabled a significant improvement in amplitude gainin the initial time and after one month of therapy (p= 0.002), maintaining the amplitude until the third month, without showing any significant gain. Conclusions:For the variable mouth opening amplitude, physiotherapy is shown to be a good treatment alternative, achieving satisfactory results for gaining amplitude and improving the patient's symptomatic condition (AU).

Introducción: El trastorno temporomandibular, un trastorno que afecta las estructuras óseas, musculares y articulares en la región orofacial, ha sido cada vez más recurrente. Este trastorno causa dolor, limitación de movimiento y cambios en la calidad de vida de los pacientes afectados por la enfermedad. Son necesarias medidas de control y tratamiento de la enfermedad de prevalencia creciente.Objetivo: Evaluar la amplitud de la apertura de la boca en pacientes con disfunción temporomandibular, sometidos a tratamiento con fisioterapia después de 1 y 3 meses de tratamiento.Metodología: Se evaluó la amplitud de la apertura de la boca en 25 pacientes sometidos a tratamiento de fisioterapia. Todos los pacientes fueron diagnosticados con trastorno de acuerdo con el eje 1 del Criterios de diagnóstico de investigación para trastornos temporomandibulares. Los datos recopilados se evaluaron utilizando el programa SPSS y se realizó la prueba de Wilcoxon, con un nivel de confianza del 95%. Resultados: Para los pacientes que presentaron deterioro de la amplitud máxima de apertura sin asistencia, la fisioterapia permitió una mejora significativa en la ganancia de amplitud en el tiempo inicial ydespués de un mes de terapia (p=0,002), manteniendo la amplitud hasta el tercer mes, sin mostrar ninguna ganancia significativa.Conclusiones: Para la amplitud variable de apertura de la boca, se muestra que la fisioterapia es una buena alternativa de tratamiento, logrando resultados satisfactorios para aumentar la amplitud y mejorar la condición sintomática del paciente (AU).

MMP-7 and MMP-9 are overexpressed in the synovial tissue from severe temporomandibular joint dysfunction.

Matrix metalloproteinases (MMPs) are tissue-enzymes that play a key role during the remodeling process, such as in inflammatory diseases. MMP-7 and MMP-9 have been shown to be implicated in extracellular matrix homeostasis and in joint disc remodeling. The objective of this study was to determine the relation of MMP-7 and MMP-9 expression with severe temporomandibular joint dysfunction, in particular with anterior disk displacement without reduction (ADDwoR), using an immunohistochemical approach. Therefore, twenty human temporomandibular synovia in the test group and ten in the control group were collected. The results showed there was a statistically significant difference (P<0.001) for morphometric and densitometric analysis of both detected MMPs in control and test groups. In conclusion, MMP-7 and MMP-9 were overexpressed in the synovial tissue of patients with ADDwoR.

Myofascial Pain: Ultrasound Width of the Masseter Muscle.

AIMS: To determine whether subjects with temporomandibular disorders (TMD) manifesting as chronic myofascial pain (MFP) involving the masseter muscle present with significantly greater masseter muscle width, as evidenced by ultrasound, compared to individuals without MFP. METHODS: A case-control study was carried out. A total of 31 subjects presenting with MFP of the masticatory muscles involving the masseter muscle and 35 controls with TMD but no diagnosis of MFP, matched by age and sex, were included. Ultrasound was used to measure the maximum width of both masseter muscles at the intermediate point between the origin and insertion of the muscle in the light occlusal contact (LOC) position and under maximum contraction. Each side was analyzed separately. Means were compared by using single-factor analysis of variance and Mann-Whitney U test; P < .05 was considered to reflect statistical significance. RESULTS: In the study group, the right masseter muscle had a mean ± standard deviation width of 8.6 ± 1.8 mm under LOC (controls: 8.6 ± 1.6 mm; P = .85) and 11.5 ± 2.1 mm under maximum contraction (controls: 11.7 ± 1.9 mm; P = .86). The analagous measures in the left masseter muscle were 8.6 ± 1.6 mm under LOC (controls: 8.2 ± 1.5 mm; P = .42) and 11.3 ± 1.8 mm under maximum contraction (controls: 11.5 ± 1.8 mm) (P = .79), respectively. The increase in width of the right masseter muscle was 2.9 ± 2.1 mm (controls: 3.1 ± 1.2 mm; P = .67) in absolute terms and 1.4 ± 0.3 mm (controls: 1.4 ± 0.2 mm; P = .91) in relative values (width at maximum contraction/LOC width). In the case of the left masseter muscle, the respective values were 2.8 ± 1.7 mm (controls: 3.2 ± 0.9 mm; P = .25) and 1.3 ± 0.2 mm (controls: 1.4 ± 0.1 mm; P = .32). CONCLUSION: There were no statistically significant differences in masseter muscle width between MFP subjects and control subjects under LOC conditions or maximum contraction. The increase in width under maximum contraction was likewise not significantly different between the groups.

Estradiol upregulates voltage-gated sodium channel 1.7 in trigeminal ganglion contributing to hyperalgesia of inflamed TMJ.

BACKGROUND: Temporomandibular disorders (TMDs) have the highest prevalence in women of reproductive age. The role of estrogen in TMDs and especially in TMDs related pain is not fully elucidated. Voltage-gated sodium channel 1.7 (Nav1.7) plays a prominent role in pain perception and Nav1.7 in trigeminal ganglion (TG) is involved in the hyperalgesia of inflamed Temporomandibular joint (TMJ). Whether estrogen could upregulate trigeminal ganglionic Nav1.7 expression to enhance hyperalgesia of inflamed TMJ remains to be explored. METHODS: Estrous cycle and plasma levels of 17ß-estradiol in female rats were evaluated with vaginal smear and enzyme linked immunosorbent assay, respectively. Female rats were ovariectomized and treated with 17ß-estradiol at 0 µg, 20 µg and 80 µg, respectively, for 10 days. TMJ inflammation was induced using complete Freund's adjuvant. Head withdrawal thresholds and food intake were measured to evaluate the TMJ nociceptive responses. The expression of Nav1.7 in TG was examined using real-time PCR and western blot. The activity of Nav1.7 promoter was examined using luciferase reporter assay. The locations of estrogen receptors (ERα and ERß), the G protein coupled estrogen receptor (GPR30), and Nav1.7 in TG were examined using immunohistofluorescence. RESULTS: Upregulation of Nav1.7 in TG and decrease in head withdrawal threshold were observed with the highest plasma 17ß-estradiol in the proestrus of female rats. Ovariectomized rats treated with 80 µg 17ß-estradiol showed upregulation of Nav1.7 in TG and decrease in head withdrawal threshold as compared with that of the control or ovariectomized rats treated with 0 µg or 20 µg. Moreover, 17ß-estradiol dose-dependently potentiated TMJ inflammation-induced upregulation of Nav1.7 in TG and also enhanced TMJ inflammation-induced decrease of head withdrawal threshold in ovariectomized rats. In addition, the estrogen receptor antagonist, ICI 182,780, partially blocked the 17ß-estradiol effect on Nav1.7 expression and head withdrawal threshold in ovariectomized rats. ERα and ERß, but not GPR30, were mostly co-localized with Nav1.7 in neurons in TG. In the nerve growth factor-induced and ERα-transfected PC12 cells, 17ß-estradiol dose-dependently enhanced Nav1.7 promoter activity, whereas mutations of the estrogen response element at -1269/-1282 and -1214/-1227 in the promoter completely abolished its effect on the promoter activity. CONCLUSION: Estradiol could upregulate trigeminal ganglionic Nav1.7 expression to contribute to hyperalgesia of inflamed TMJ.

Anatomical changes within the medullary dorsal horn in chronic temporomandibular disorder pain.

Accumulated evidence from experimental animal models suggests that neuroplastic changes at the dorsal horn are critical for the maintenance of various chronic musculoskeletal pain conditions. However, to date, no study has specifically investigated whether neuroplastic changes also occur at this level in humans. Using brain imaging techniques, we sought to determine whether anatomical changes were present in the medullary dorsal horn (spinal trigeminal nucleus caudalis) in subjects with the chronic musculoskeletal pain. In twenty-two subjects with painful temporomandibular disorders (TMDs) and forty pain-free controls voxel based morphometry of T1-weighted anatomical images and diffusion tensor images were used to assess regional grey matter volume and microstructural changes within the brainstem and, in addition, the integrity of ascending pain pathways. Voxel based morphometry revealed significant regional grey matter volume decreases in the medullary dorsal horn, in conjunction with alterations in diffusivity properties, namely an increase in mean diffusivity, in TMD subjects. Volumetric and mean diffusivity changes also occurred in TMD subjects in regions of the descending pain modulation system, including the midbrain periaqueductal grey matter and nucleus raphe magnus. Finally, tractography revealed altered diffusivity properties, namely decreased fractional anisotropy, in the root entry zone of the trigeminal nerve, the spinal trigeminal tract and the ventral trigeminothalamic tracts of TMD subjects. These data reveal that chronic musculoskeletal pain in humans is associated with discrete alterations in the anatomy of the medullary dorsal horn, as well as its afferent and efferent projections. These neural changes may be critical for the maintenance of pathological pain.

An osteochondroma of the mandibular condyle.

OBJECTIVE: Osteochondroma is rarely seen in the facial region, especially around the condyle. Here, we report a case of condylar osteochondroma, aiming to assist the diagnosis and treatment of the tumor. METHODS: A case of osteochondroma of the left mandibular condyle in a 49-year-old man was presented. Medical records with x-ray, computed tomographic scan, and bone scan of histologically proven osteochondroma of mandibular condyle were obtained. RESULTS: The patient underwent a surgical resection and had fewer functional changes as well as less dysfunction of the temporomandibular joint. CONCLUSIONS: The current study highlights the fact that, despite its rarity in the mandibular condyle, surgical resection is an effective treatment method. The decision, however, depends on how much swing of the mandible is required after surgery for correction of asymmetry and occlusion.

Surgical treatment of temporomandibular disorder in a 24-year-old male patient with ganglion cyst.

Ganglion cysts are common pseudocystic masses, whereas those arising from the temporomandibular joint (TMJ) are rare entities. We report a case of ganglion cyst of the right TMJ with symptomatic bilateral TMJ internal derangement in a 24-year-old man. Disk repositioning using bone anchors and excision of the ganglion cyst were performed. A unique characteristic of inflammatory infiltrates was revealed in the specimen, and the relationship between these 2 distinct entities and probable pathogenesis of infectious involvement are discussed.

[Features of the hormonal status in patients with temporomandibular joint dysfunction and class II malocclusion].

The article presents data on androgen levels in female patients with temporomandibular joint (TMJ) dysfunction of varying degree and class II malocclusion. The study revealed significant correlation between degenerative and inflammatory TMJ changes and androgens level in patients with stigmas of connective tissue dysplasia (p<0.05), probably due to indirect proinflammatory action of androgens as they stimulate inflammatory mediators expression.

[The peculiarities of petrotympanic fissure topography in Costen syndrome and possible causes of its development].

A complex study of morphometric characteristics of the articular surfaces of the temporomandibular joint and the examination of the peculiarities of the petrotympanic fissure topography were performed on 138 samples of skulls of adult individuals with intact occlusion, complete anodontia and different forms of cranial skull (dolicho-, meso- and brachicranial). No distinct differences in studied parameters were found between the studied groups. However, in the hypsicranial group the petrotympanic fissure was found to pass more often through the medial third of the mandibular fossa, which may be a predisposing anatomical factor for Costen syndrome. Due to the fact that in anodontia the parameters characterizing the articular surfaces of the temporomandibular joint, are significantly changed, the immediate cause of the Costen syndrome are the changes of the articular surfaces of the temporomandibular joint, primarily the reduction in the size of mandibular condyle, which is accompanied by its pathological displacement and compression of the chorda tympani.

Early-lethal Costello syndrome due to rare HRAS Tandem Base substitution (c.35_36GC>AA; p.G12E)-associated pulmonary vascular disease.

Costello syndrome is a rare, autosomal-dominant syndrome caused by activating missense mutations in the Harvey rat sarcoma viral oncogene homolog (HRAS), most often p.G12S. Several rare mutations have consistently been associated with a more severe phenotype that is often lethal in infancy. Cause of death is most often respiratory failure, with hypertrophic cardiomyopathy playing a significant role in morbidity. Impaired fibroblast elastogenesis is thought to contribute to the Costello phenotype, but reports of histologic evidence of disordered elastogenesis at autopsy are limited. We report a patient with Costello syndrome due to a rare tandem base substitution (c.35_36GC>AA) resulting in the p.G12E missense change. The proband died at the age of 3 months from respiratory failure, with minimal evidence of cardiomyopathy. The autopsy disclosed pulmonary vascular dysplasia affecting small arteries and veins associated with abnormal elastin distribution in tortuous dilated arteries and veins, with nonuniform wall thickness and semiobstructive lesions at artery branch points typical of early pulmonary hypertensive vascular disease. Elastic fibers in the dermis were abnormally short and fragmented. This case suggests that disordered elastogenesis in the pulmonary vasculature and undiagnosed (or underdiagnosed) pulmonary hypertension may contribute to morbidity in patients with Costello syndrome.

Differential diagnostics of pain in the course of trigeminal neuralgia and temporomandibular joint dysfunction.

Chronic oral and facial pain syndromes are an indication for intervention of physicians of numerous medical specialties, while the complex nature of these complaints warrants interdisciplinary diagnostic and therapeutic approach. Oftentimes, lack of proper differentiation of pain associated with pathological changes of the surrounding tissues, neurogenic pain, vascular pain, or radiating pain from idiopathic facial pain leads to improper treatment. The objective of the paper is to provide detailed characterization of pain developing in the natural history of trigeminal neuralgia and temporomandibular joint dysfunction, with particular focus on similarities accounting for the difficulties in diagnosis and treatment as well as on differences between both types of pain. It might seem that trigeminal neuralgia can be easily differentiated from temporomandibular joint dysfunction due to the acute, piercing, and stabbing nature of neuralgic pain occurring at a single facial location to spread along the course of the nerve on one side, sometimes a dozen or so times a day, without forewarning periods. Both forms differ significantly in the character and intensity of pain. The exact analysis of the nature, intensity, and duration of pain may be crucial for the differential diagnostics of the disorders of our interest.

Disc and condylar head position in the temporomandibular joint with and without disc displacement.

The purpose of this study was to evaluate the difference between disc and condyle position between temporomandibular joints (TMJs) without disc displacement (DD) in asymptomatic volunteers, and patients who have DD in contralateral joints, respectively unilateral DD. Secondly, there were two TMJ groups which consisted of measurements from patients' symptomatic DD and volunteers with asymptomatic DD. The study included 79 TMJs of 40 patients with unilateral DD. In the group of 25 asymptomatic volunteers, 20 volunteers were without DD bilaterally (40 joints), while five had DD in at least one TMJ. All subjects were examined clinically and DD was confirmed by magnetic resonance imaging. Left and right TMJs were analysed independently for each participant based on their DD status (symptomatic, asymptomatic, and without DD). All asymptomatic TMJs did not have any clinical signs of TMJ functional abnormalities. There was a significant statistical difference between disc position among TMJs without DD in asymptomatic volunteers and TMJs without DD in patients (p = 0.016). Moreover, no significant differences were found between condyle position in the same groups of joints (p = 0.706). There were no significant differences in the DD position (p = 0.918) or condyle position (p = 0.453) between the group with asymptomatic volunteers' joints and the group with symptomatic patients' joints. There was a significant difference between patient and volunteers' joints without DD: the disc was positioned more anteriorly in patients' joints without DD than in joints of asymptomatic volunteers without DD.

Signos y síntomas en pacientes con síndrome de disfunción temporomandibular

Introducción: el síndrome de disfunción temporomandibular es sin dudas un problema de salud cuya etiopatogenia y manejo terapéutico constituye todo un reto para el profesional. El mismo con frecuencia, pasa inadvertido por la falta de un examen clínico completo y minucioso que incluya el estudio de la articulación temporomandibular.Objetivo: caracterizar clínicamente el comportamiento del síndrome de disfunción temporomandibular en pacientes aquejados de esta afección.Métodos: estudio descriptivo de corte transversal. Universo constituido por pacientes con diagnóstico de síndrome de disfunción temporomandibular, que acudieron a la consulta externa o cuerpo de guardia de Cirugía Maxilofacial del Hospital Universitario Miguel Enríquez; en el período comprendido desde junio de 2011 hasta marzo de 2012. Se confeccionó una planilla para la recolección de la información con variables como: edad, sexo, ruido articular, dolor muscular, dolor articular, deflexión mandibular y clasificación clínica.Resultados: el sexo femenino prevaleció sobre el masculino con un 72,59 por ciento. El grupo de edad más representativo fue el de 20 a 29 años con 23,35 por ciento. Predominó el dolor articular con un 58,88 por ciento. El chasquido inicial fue el ruido común para un 26,39 por ciento. En su mayoría los pacientes no presentaron deflexión mandibular. El estadio de Wilkes más representado fue el I con 43,15 por ciento.Conclusiones: el sexo femenino y el grupo etáreo de 20 a 29 años fueron los más afectados. Predominó el dolor articular, la ausencia de deflexión mandibular y el ruido más común fue el chasquido inicial. El estadio I de Wilkes resultó el más representado (AU)

Introduction: temporomandibular dysfunction syndrome is undoubtedly a health problem whose etiopathogeny and therapeutic management represents a challenge for the professional. The same often goes unnoticed due to the lack of a complete and thorough clinical examination including the study of the temporomandibular joint.Objective: to clinically characterize the behavior of temporomandibular dysfunction syndrome in patients afflicted with this condition.Methods: a descriptive cross-sectional study. Universe consisting of patients diagnosed with temporomandibular dysfunction syndrome, who attended the outpatient consultation room or emergency department Maxillofacial Surgery of Miguel Enríquez University Hospital, in the period from June 2011 to March 2012. It was made a chart for the collection of information variables such as: age, sex, joint noise, muscle pain, joint pain, mandibular deflection and clinical classification.Results: female on male prevailed with 72,59 per cent. The most representative age group was 20 to 29 years with 23,35 per cent . Joint pain predominated with 58,88 per cent. The initial clicking was the common noise for 26,39 per cent. Most of the patients had no mandibular deflection. Wilkes stage I was the most represented with 43,15 per cent.Conclusions: Female sex and age group of 20-29 years were the most affected. Joint pain predominated, lack of mandibular deflection and the most common noise was the initial clicking. Wilkes stage I was the most represented (AU)

Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion.

Temporomandibular joint disorder (TMJD) is known for its mastication-associated pain. TMJD is medically relevant because of its prevalence, severity, chronicity, the therapy-refractoriness of its pain, and its largely elusive pathogenesis. Against this background, we sought to investigate the pathogenetic contributions of the calcium-permeable TRPV4 ion channel, robustly expressed in the trigeminal ganglion sensory neurons, to TMJ inflammation and pain behavior. We demonstrate here that TRPV4 is critical for TMJ-inflammation-evoked pain behavior in mice and that trigeminal ganglion pronociceptive changes are TRPV4-dependent. As a quantitative metric, bite force was recorded as evidence of masticatory sensitization, in keeping with human translational studies. In Trpv4(-/-) mice with TMJ inflammation, attenuation of bite force was significantly less than in wildtype (WT) mice. Similar effects were seen with systemic application of a specific TRPV4 inhibitor. TMJ inflammation and mandibular bony changes were apparent after injections of complete Freund adjuvant but were remarkably independent of the Trpv4 genotype. It was intriguing that, as a result of TMJ inflammation, WT mice exhibited significant upregulation of TRPV4 and phosphorylated extracellular-signal-regulated kinase (ERK) in TMJ-innervating trigeminal sensory neurons, which were absent in Trpv4(-/-) mice. Mice with genetically-impaired MEK/ERK phosphorylation in neurons showed resistance to reduction of bite force similar to that of Trpv4(-/-) mice. Thus, TRPV4 is necessary for masticatory sensitization in TMJ inflammation and probably functions upstream of MEK/ERK phosphorylation in trigeminal ganglion sensory neurons in vivo. TRPV4 therefore represents a novel pronociceptive target in TMJ inflammation and should be considered a target of interest in human TMJD.

Correlation between articular eminence steepness measured with cone-beam computed tomography and clinical dysfunction index in patients with temporomandibular joint dysfunction.

OBJECTIVE: The purpose of this study was to investigate the correlation between articular eminence steepness and clinical dysfunction index (Di) in patients with temporomandibular joint dysfunction (TMD) using cone-beam computed tomography (CBCT). STUDY DESIGN: In this study, CBCT images of 60 temporomandibular joints in 30 patients with TMD were evaluated. The eminence inclination values were measured on CBCT images. Patients were subdivided into 3 groups based on Helkimo's clinical Di. The data were analyzed using Spearman's rho correlation coefficient test. RESULTS: The results of the present study did not confirm any significant differences in the values of articular eminence inclinations among the 3 groups (P value >.05). CONCLUSION: Based on the present study, there is no apparent relationship between the articular eminence inclination and the clinical Di in patients with TMD.

Lavage treatment of painful jaw movements at disc displacement without reduction. A randomized controlled trial in a short-term perspective.

This study compared the short-term efficacy of two treatments (local anesthetics (A) and local anesthetics and lavage (AL)) in patients with permanently displaced discs and temporomandibular disorder (TMD) pain. 45 patients participated in the single-blind randomized controlled trial. All patients had received: a Research Diagnostic Criteria/TMD diagnosis of disc displacement without reduction; and magnetic resonance imaging confirmation of non-reducing disc displacement. Participants were randomized to treatment with A or AL and were assessed at baseline and at 1 and 3 month follow-ups. The primary outcome measure defining success was reduction in pain intensity of at least 30% during jaw movement. At the 3 month follow-up, the success rate was 76% for A and 55% for AL. Both groups reported similar pain relief with no significant difference between the groups. Similar trends were observed for outcome measures in the physical functioning, emotional functioning, and global improvement domains with no significant difference between the groups. Use of lavage to supplement extra-articular local anesthetic treatment of painful jaw movements at non-reducing discs does not appear to improve TMD pain and mouth opening capacity in the short term.